发明名称 |
Chromatography Media And Method |
摘要 |
Adsorptive media for chromatography, particularly ion-exchange chromatography, derived from a shaped fiber. In certain embodiments, the functionalized shaped fiber presents a fibrillated or ridged structure which greatly increases the surface area of the fibers when compared to ordinary fibers. Also disclosed herein is a method to add surface pendant functional groups that provides cation-exchange or anion-exchange functionality to the high surface area fibers. This pendant functionality is useful for the ion-exchange chromatographic purification of biomolecules, such as monoclonal antibodies (mAbs). |
申请公布号 |
US2012029176(A1) |
申请公布日期 |
2012.02.02 |
申请号 |
US201113191992 |
申请日期 |
2011.07.27 |
申请人 |
YAVORSKY DAVID;AMARA JOHN;UMANA JOAQUIN;CATALDO WILLIAM;KOZLOV MIKHAIL;STONE MATTHEW;MILLIPORE CORPORATION |
发明人 |
YAVORSKY DAVID;AMARA JOHN;UMANA JOAQUIN;CATALDO WILLIAM;KOZLOV MIKHAIL;STONE MATTHEW |
分类号 |
B01D15/08;B01D15/04;B01D15/10;B01D15/32;B01D15/36;B01D15/38;C07K1/18;C07K1/20;C07K1/22 |
主分类号 |
B01D15/08 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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