DOCETAXEL-LOADED THERMOSENSITIVE LIQUID SUPPOSITORY COMPOSITION FOR RECTAL ADMINISTRATION

摘要

The present invention relates to a novel docetaxel-loaded thermosensitive liquid suppository composition for rectal administration, which have properties in that it exists as a liquid at room temperature and forms a gel in vivo so as to adhere to the mucosa. The composition contains 25-35 wt% poloxamer, 2-10 wt% polysorbate 80, 54-72.99 wt% water, and 0.01-1 wt% docetaxel as an active ingredient, and has a gelation temperature of 30-36°C. This composition provides a novel, safe, convenient and effective formulation of docetaxel.