发明名称 |
Tetrahydroisoquinolin-1-one derivative or salt thereof |
摘要 |
<p>[PROBLEMS] To provide a compound which can be used as a medicinal agent, particularly a therapeutic agent for irritable bowel syndrome (IBS). [MEANS FOR SOLVING PROBLEMS] It is found that a tetrahydroisoquinolin-1-one derivative having an amide group at position-4 or a pharmaceutically acceptable salt thereof has an excellent antagonistic activity on a bombesin-2 (BB2) receptor. It is also found that the tetrahydroisoquinolin-1-one derivative is highly effective on stool abnormality. Therefore, the tetrahydroisoquinolin-1-one derivative is useful as a therapeutic agent for a disease associated with a BB2 receptor, particularly IBS.</p> |
申请公布号 |
AU2008255815(B2) |
申请公布日期 |
2012.02.02 |
申请号 |
AU20080255815 |
申请日期 |
2008.05.26 |
申请人 |
ASTELLAS PHARMA INC |
发明人 |
HISAMICHI, HIROYUKI;SHIMIZU, TAKAFUMI;MAENO, KYOICHI;ISHIKAWA, NORIKO;TAKUWA, TOMOFUMI;SEKI, NORIO;ISHIHARA, TSUKASA;SHIMADA, ITSURO |
分类号 |
C07D217/26;A61K31/472;A61K31/496;A61K31/497;A61K31/501;A61K31/506;A61K31/53;A61K31/5377;A61K31/695;A61P1/00;A61P35/00;C07D401/04;C07D401/06;C07D401/12;C07D405/04;C07D405/06;C07D405/14;C07D409/12;C07D413/12;C07D417/12;C07D453/02;C07D471/04 |
主分类号 |
C07D217/26 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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