CARVEDILOL SULFATE CRYSTALS, PREPARATION METHOD THEREOF, AND PHARMACEUTICAL USE THEREOF

摘要

Disclosed are a carvedilol sulfate form A, form B, form C or form D crystalline medicament for the treatment of hypertension, congestive heart failure, and angina pectoris, a preparation method thereof, and a pharmaceutical application thereof. The preparation method comprises: crystallizing carvedilol sulfate solid in random crystal forms or an amorphous form with common polar organic solvents and aqueous solutions thereof to obtain form A, form B, form C or form D crystals. The disclosed carvedilol sulfate crystals have strong crystal morphology, and the crystallization solvent employed is of low toxicity and low residue.