ARYL HYDROCARBON RECEPTOR (AHR) MODIFIERS AS NOVEL CANCER THERAPEUTICS
摘要
Provided herein are novel agents that modulate AhR activity for use in therapeutic compositions and methods thereof for inhibiting cancer cell proliferation and tumor cell invasion and metastasis. The agents comprise AhR inhibitors or non-constitutive AhR agonists of Formula (I) and (II) for the inhibition of cancer cell growth and parameters that characterize tumor metastasis, such as tumor cell invasiveness.
申请公布号
CA2807199(A1)
申请公布日期
2012.02.02
申请号
CA20112807199
申请日期
2011.07.27
申请人
TRUSTEES OF BOSTON UNIVERSITY;NORTHEASTERN UNIVERSITY;BOSTON MEDICAL CENTER CORPORATION
发明人
SHERR, DAVID H.;POLLASTRI, MICHAEL;SCHLEZINGER, JENNIFER;HAIGH MOLINA, SARAH;SCHAUS, SCOTT;GIGUERE, JOSHUA ROBERT