发明名称 |
ANTISENSE COMPOUND FOR INDUCING IMMUNOLOGICAL TOLERANCE |
摘要 |
A method and conjugate for selectively killing antigen-activated T cells are disclosed. The conjugate is composed of a substantially uncharged antisense compound targeted against the human cFLIP protein, and a reverse TAT (rTAT) polypeptide coupled covalently to the antisense compound. The rTAT polypeptide is effective to produce selective uptake of the conjugate into antigen-activated T cells, relative to the uptake of the conjugate into non-activated T cells. The cFLIP antisense compound causes activation induced cell death (AICD) of activated lymphocytes. The method is useful in treating transplantation rejection and autoimmune conditions. |
申请公布号 |
US2012027791(A1) |
申请公布日期 |
2012.02.02 |
申请号 |
US201113187338 |
申请日期 |
2011.07.20 |
申请人 |
MOURICH DAN V.;MOULTON HONG MU;HINRICHS DAVID J.;IVERSEN PATRICK L.;AVI BIOPHARMA, INC. |
发明人 |
MOURICH DAN V.;MOULTON HONG MU;HINRICHS DAVID J.;IVERSEN PATRICK L. |
分类号 |
A61K38/14;A61K;A61K31/675;A61K48/00;A61P37/06;C07K9/00;C12N5/0781;C12N5/0783;C12N5/0784;C12N15/113 |
主分类号 |
A61K38/14 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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