发明名称 |
MESENCHYMAL STEM CELLS PRODUCING INHIBITORY RNA FOR DISEASE MODIFICATION |
摘要 |
Compositions and methods for delivering a siRNA, dsRNA, or miRNA polynucleotide into a target cell comprising contacting the target cell with a mesenchymal stem cell, which mesenchymal stem cell comprises an exogenous DNA sequence expressing the siRNA or dsRNA polynucleotide, thereby delivering the siRNA, dsRNA, or miRNA polynucleotide to the target cell through a cellular protrusion or a microvesicle. |
申请公布号 |
EP2411505(A2) |
申请公布日期 |
2012.02.01 |
申请号 |
EP20100756864 |
申请日期 |
2010.03.25 |
申请人 |
THE REGENTS OF THE UNIVERSITY OF CALIFORNIA |
发明人 |
NOLTA, JAN A.;OLSON, SCOTT;WIRTHLIN, LOUISA |
分类号 |
C12N5/0775;A61K48/00;A61P25/00;C12N5/10;C12N15/11;C12N15/87 |
主分类号 |
C12N5/0775 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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