Disclosed herein are zinc fingers comprising CCHC zinc coordinating residues. Also described are zinc finger proteins and fusion proteins comprising these CCHC zinc fingers as well as polynucleotides encoding these proteins. Methods of using these proteins for gene editing and gene regulation are also described.
申请公布号
EP2412812(A1)
申请公布日期
2012.02.01
申请号
EP20110184941
申请日期
2007.12.13
申请人
DOW AGROSCIENCES, LLC;SANGAMO BIOSCIENCES, INC.
发明人
CAI, QIHUA C.;MILLER, JEFFREY;URNOV, FYODOR;SHUKLA, VIPULA K.;PETOLINO, JOSEPH F.;BAKER, LISA W.;GARRISON, ROBBI J.;BLUE, RYAN C.;MITCHELL, JON C.;ARNOLD, NICOLE L.;WORDEN, SARAH E.
