发明名称 |
Streptomyces Avermitilis gene directing the ratio of B2:B1 avermectins |
摘要 |
The present invention relates to polynucleotide molecules comprising nucleotide sequences encoding an aveC gene product, which polynucleotide molecules can be used to alter the ratio or amount of class 2:1 avermectins produced in fermentation cultures of S. avermitilis. The present invention further relates to vectors, host cells, and mutant strains of S. avermitilis in which the ave C gene has been inactivated, or mutated so as to change the ratio or amount of class 2:1 avermectins produced. |
申请公布号 |
SI2050815(T1) |
申请公布日期 |
2012.01.31 |
申请号 |
SI20030032087T |
申请日期 |
2003.01.31 |
申请人 |
PFIZER PRODUCTS INC. |
发明人 |
STUTZMAN-ENGWALL KIM JONELLE;GUSTAFSSON CLAES ERIC DANIEL;KREBBER ANKE;RAILLARD SUN AI;MINSHULL JEREMY STEPHEN;KIM SERAN;CHEN YAN |
分类号 |
C12N9/88;C12N15/09;A61K31/7048;A61P33/00;C12N1/15;C12N1/19;C12N1/21;C12N5/10;C12N15/11;C12N15/31;C12N15/60;C12N15/74;C12P17/18;C12P19/62;C12R1/465 |
主分类号 |
C12N9/88 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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