发明名称 |
Variants of pigment epithelium derived factor and uses thereof |
摘要 |
The present invention relates to anti-angiogenic variants of pigment epithelium derived factor (PEDF) comprising a plurality of altered phosphorylation sites, polynucleotides encoding same and uses thereof. In particular, the PEDF variants of the present invention provide superior anti-angiogenic activity and high neurotrophic activity and are useful in treating diseases associated with neovascularization and with neurodegenerative conditions.
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申请公布号 |
US8106010(B2) |
申请公布日期 |
2012.01.31 |
申请号 |
US20060093576 |
申请日期 |
2006.11.14 |
申请人 |
MAIK-RACHLINE GALIA;SEGER RONY;YEDA RESEARCH AND DEVELOPMENT CO. LTD. AT THE WEIZMANN INSTITUTE OF SCIENCE |
发明人 |
MAIK-RACHLINE GALIA;SEGER RONY |
分类号 |
A61K38/04;C07K14/47;C12N15/63;C12P21/06 |
主分类号 |
A61K38/04 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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