| 摘要 |
THE PRESENT INVENTION RELATES TO THE USE OF CERTAIN DERIVATIVES OF OXAZOLES , THIAZOLES IMIDAZOLES AND ISOXAZOLINES FOR PREPARING MEDICAMENT INTENDED TO INHIBIT MONOAMINE OXYDASES (MAO) AND/OR TO ACTAS MODULATORSOF THE SODIUM CHANNELS . A PARTICULAR SUBJECT OF THE INVENTION IS THE USE OF SAID DERIVATIVES FOR PREPARING A MEDICAMENT INTENDED TO TREAT ONE OF THE FOLLOWING DISORDERS OR DISEASES: PARKINSON''S DISEASE, SENILE DEMENTIA, ALZHEIMEIR''S DISEASE, HUNTINGTON''S CHOREA, LATERAL AMYOTTROPHIC SCLEROSIS, SCHIZOPHRENIA, DEPRESSION , PSYCHOSES AND PAIN AND EPILEPSY.THE INVENTION RELATES IN PARTICULAR TO THE FOLLOWING COMPOUNDS: -4-[3,5-BIS(1,1-DIMETHYLETHYL)-4-HYDROXYPHENYL]-NMETHYL-2-THIAZOLEMETHANAMINE;-2-[(<4-[3,5-DI(TER-BUTYL)-4-HYDROXYPHENYL] -1,3-THIAZOL-2-Y1>METHYL) (METHYL)AMINO]-ACETONITRILE;-2,6-DI(TERT-BUTYL)-4-(2-<[(2-HYDROXYETHYL) (METHYL)AMINO]METHYL>-1,3-THIAZOL-4-YL)-PHENOL;-3-[3,5-BIS(1,1-DIMETHYLETHYL)-4-HYDROXYPHENYL]-4,5-DIHYDRO-5-ISOXAZOLEETHANOL;-(1R)-N-BENZYL-2-(1H-INDOL-3-YL)-1-(4-PHENYL-1H-IMIDAZOL-2-YL)ETHANAMINE;OR THEIR SALTS.
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