发明名称 |
Human anti-NGF neutralizing antibodies as selective NGF pathway inhibitors |
摘要 |
This invention provides antibodies that interact with or bind to human nerve growth factor (NGF) and neutralize the function of NGF thereby. The invention also provides pharmaceutical compositions of these antibodies and methods for neutralizing NGF function, and particularly for treating NGF-related disorders (e.g., chronic pain) by administering a pharmaceutically effective amount of anti-NGF antibodies. Methods of detecting the amount of NGF in a sample using anti-NGF antibodies are also provided. |
申请公布号 |
US8106167(B2) |
申请公布日期 |
2012.01.31 |
申请号 |
US20100859246 |
申请日期 |
2010.08.18 |
申请人 |
WILD, JR. KENNETH D.;TREANOR JAMES J. S.;HUANG HAICHUN;INOUE HEATHER;ZHANG TIE J.;MARTIN FRANK;AMGEN INC. |
发明人 |
WILD, JR. KENNETH D.;TREANOR JAMES J. S.;HUANG HAICHUN;INOUE HEATHER;ZHANG TIE J.;MARTIN FRANK |
分类号 |
C07K16/18;A61K39/395;C07K16/22;G01N33/53 |
主分类号 |
C07K16/18 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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