发明名称 |
Succinic acid diester derivative, process for production thereof, and use of the derivative in the production of pharmaceutical preparation |
摘要 |
The present invention provides with a process of preparing an optically active succinimide derivative, which is a key intermediate for production of ranirestat. A compound (3) is easily prepared by treating the derivative of succinic acid diester of the formula (2): wherein R1 is an amino group protected with a group removed by hydrogenolysis or a tert-butoxycarbonylamino group and R2 is an ethyl group optionally substituted with one or two methyl group(s) at α-position, provided that R2 is not a tert-butyl group when R1 is a tert-butoxycarbonylamino group; with alkali metal alkoxide and the compound (3) can be an important intermediate for production of ranirestat. |
申请公布号 |
US8106230(B2) |
申请公布日期 |
2012.01.31 |
申请号 |
US20070310524 |
申请日期 |
2007.08.30 |
申请人 |
INAGAKI TAKASHI;YAMAKAWA YOSHIKAZU;DAINIPPON SUMITOMO PHARMA CO., LTD.;KATAYAMA SEIYAKUSYO CO., LTD. |
发明人 |
INAGAKI TAKASHI;YAMAKAWA YOSHIKAZU |
分类号 |
C07C255/03 |
主分类号 |
C07C255/03 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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