2,4,5-TRISUBSTITUTED THIAZOLYL DERIVATIVES ANT THEIR ANTIINFLAMMATORY ACTIVITY

摘要

This invention concerns the use of a compound of formula (I) a N-oxide, a pharmaceutically acceptable addition salt, a quaternary amine and a stereochemically isomeric form thereof, wherein Z is halo; C_1-6alkyl; C_1-6alkyl substituted with hydroxy, carboxyl, cyano, amino, mono- or di(C_1-6alkyl)amino, aminocarbonyl, mono- or di(C_1-6alkyl)aminocarbonyl, C_1-6alkyloxycarbonyl or C_1-6alkyloxy; polyhaloC_1-4alkyl; C_1-4alkyloxy; cyano; amino; aminocarbonyl; mono- or di(C_1-6alkyl)aminocarbonyl; C_1-6alkyloxycarbonyl; C_1-6alkylcarbonyloxy; H₂N-S(-O)₂-; mono- or di(C_1-6alkyl)amino-S(-O)₂; -C(-N-R^x)NR^yR^z; Q is an optionally substituted carbocycle or an optionally substituted heterocycle; L is substituted phenyl or an optionally substituted monocyclic 5 or 6-membered partially saturated or aromatic heterocycle or a bicyclic partially saturated or aromatic heterocycle; aryl is optionally substituted phenyl; for the manufacture of a medicament for the prevention or the treatment of diseases mediated through TNF-alpha and/or IL-12.