发明名称 |
Ethyl 3-?á(2-?í?á4-Hexyloxycarbonylamino-imino-methyl)-phenylamino?å-methyl?ç-1-methyl-1H-benzimidazol-5-carbonyl)-pyridin-2-yl-amino?å-propionate methanesulfonate hemihydrate and its use as a medicament |
摘要 |
<p>Ethyl 3-(N-(2-(4-(hexyloxycarbonylamidino)phenylaminomethyl)-1-methyl-1H-benzimidazole-5-carbonyl)-N-(2-pyridyl)amino)propionate methanesulfonate polymorph I (Ia), polymorph II (Ib) and hemihydrate (Ic), with melting points of 180+-3[deg]C, 190+-3[deg]C and 120+-5[deg]C respectively, are new. Independent claims are also included for the preparation of (Ia)-(Ic). ACTIVITY : Anticoagulant; Cerebroprotective; Vasotropic. No biological data is given. MECHANISM OF ACTION : Thrombin inhibitor.</p> |
申请公布号 |
SI2060569(T1) |
申请公布日期 |
2012.01.31 |
申请号 |
SI20040031794T |
申请日期 |
2004.08.24 |
申请人 |
BOEHRINGER INGELHEIM INTERNATIONAL GMBH |
发明人 |
SIEGER PETER;SOBOTTA RAINER;SCHMID ROLF |
分类号 |
A61K31/4427;A61K31/4439;A61P7/02;C07D401/12 |
主分类号 |
A61K31/4427 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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