发明名称 |
BIOMARKERS AND METHODS FOR DETERMINING EFFICACY OF ANTI-EGFR ANTIBODIES IN CANCER THERAPY |
摘要 |
<p>The invention relates to biomarkers based on gene expression products and methods for determining the efficacy of anti-EGFR antibodies in the treatment of EGFR expressing cancer. The invention is further related to the prediction of sensitivity or resistance of a patient suffering from EGFR expressing cancer to the treatment of said patient with a specific anti- EGFR antibody. The invention is preferably related to the identification of respective biomarkers that allow a better prediction of the clinical outcome of the treatment with anti- EGFR antibodies in patients with KRAS wild-type tumors. In this context, the invention especially relates to anti-EFGR antibody c225/cetuximab (Erbitux®) and its use in patients suffering from colorectal Cancer (CRC).</p> |
申请公布号 |
SG176773(A1) |
申请公布日期 |
2012.01.30 |
申请号 |
SG20110091360 |
申请日期 |
2010.06.15 |
申请人 |
MERCK PATENT GMBH |
发明人 |
STROH, CHRISTOPHER;VON HEYDEBRECK, ANJA |
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