发明名称 PHARMACEUTICAL COMPOSITIONS AND SOLID FORMS
摘要 <p>The present invention relates to pharmaceutical compositions of 6-(6-hydroxymethyl- pyrimidin-4-yloxy)-naphthalene-1-carboxyfic acid (3-trifluoromethyl-phenyl)-amide, to the use of 6-(6-hydroxymethyl-pyrimidin-4-yloxy)-naphthatene-1-carboxylic acid (3-trifluoromethyI- phenyl)-amide and compositions of 6-(6-hydroxymethyl-pyrimidin-4-yloxy)-naphthalene-1- carboxylic acid (3-trifluoromethyi-phenyi)-amide in therapeutic applications, especially indications with a dysregulation/overexpression of VEFG, (neo)-vascularisation and VEGF driven angiogenesis and to methods for manufacturing such compositions, the invention further relates to specific forms of 6-(6-hydroxymethyl-pyrimidin-4-yloxy)-πaphthalene-1- carboxyiic acid (3-trifluαromethyl-phenyl)-amide and to the manufacturing and use of such forms. The present invention also relates to a new process to produce 6-{6-hydroxymethyl- pyrimidin-4-yloxy)-naphthalene-1-carboxylic acid (3-trifluoromethyl-phenyl)-amide.</p>
申请公布号 SG176955(A1) 申请公布日期 2012.01.30
申请号 SG20110095205 申请日期 2010.07.05
申请人 NOVARTIS AG 发明人 BERGHAUSEN, JOERG;HAUG, CLAIRE;HERBIG, MICHAEL;HU, BIN;JONAT, STEPHANE;LELETI, RAJENDER;MEINGASSNER, JOSEF GOTTFRIED;MONNIER, STEPHANIE;NAPP, MATTHIAS;PRASHAD, MAHAVIR;STUETZ, ANTON;THAKUR, RANJIT
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