ANTIBODY TO TGF BETA AND USE THEREOF

摘要

The invention relates to immunology and medicine. An antibody is proposed to TGF&bgr; or an antigen-binding fragment thereof, a composition based on said antibody or a fragment thereof and also the use thereof as a medicament for the treatment of fibrotic disease, chronic renal disease and cancer. The antibodies or fragments therof comprise specific portions due to which they are more specifically and/or selectively bind mature TGF-&bgr; 1 over mature TGF-&bgr; 2 and/or mature TGF-&bgr; 3 and neutralize mature TGF-&bgr; 1