MULTI-SIRNA COMPOSITIONS FOR REDUCING GENE EXPRESSION

摘要

This disclosure provides formulations and compounds for use in treating disease by gene silencing and, more specifically, to formulations and compositions having multiple double- stranded nucleic acid complexes, each double- stranded nucleic acid complex comprising an antisense strand and a continuous passenger strand or a discontinuous passenger strand, where the composition decreases expression of one or more mRNA, and to uses of such formulations and compositions to treat or prevent diseases or conditions associated with inappropriate gene expression.