DIAGNOSTIC AND THERAPEUTIC METHODS AND COMPOSITIONS FOR METABOLIC DISEASE

摘要

The present invention relates to a method for the immunization or prophylaxis against, or the treatment of, metabolic diseases in a mammal, the method comprising the step of administering to the mammal a pharmaceutical composition comprising at least one platelet activating factor (PAF) conjugate, PAF derivative, or conjugate of a PAF derivative, or an antibody preparation with reactivity to PAF, a PAF conjugate, a PAF derivative, or conjugate of a PAF derivative. The metabolic disease may, for example, be a condition selected from the group consisting of metabolic syndrome, insulin resistance, glucose intolerance, hyperglycemia, type I diabetes, type II diabetes, hyperlipidemia, hypertriglyceridemia, hypercholesterolemia, dyslipidemia, and polycystic ovary syndrome (PCOS). Also provided is a method for diagnosing metabolic disease, or assessing a patient's risk of developing or progression of metabolic disease, the method comprising the steps of - (a) assessing the patient's level of antibodies with reactivity to PAF, a PAF conjugate, a PAF derivative, or conjugate of a PAF derivative; and (b) diagnosing metabolic disease or determining the patient's level of risk of developing or progression of metabolic disease based on the assessed levels of antibodies with reactivity to PAF, a PAF conjugate, a PAF derivative, or conjugate of a PAF derivative.