| 发明名称 |
SYNTHESIS OF CYCLOPENTAQUINAZOLINES |
| 摘要 |
A method of producing 6-amino-cyclopenta[g]quinazolines, in enantiomerically enriched form, is provided. In particular, the method may be applicable to the synthesis of N-{N-{4- [N-((6S)-2-hydroxymethyl-4-oxo-3,4,7,8-tetrahydro-6H-cyclo-penta[g]quinazolin-6-yl)-///- (prop-2-ynyl)amino]benzoyl}-L-?-glutamyl}-D-glutamic acid (ONX-0801 ).
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| 申请公布号 |
CA2804889(A1) |
申请公布日期 |
2012.01.26 |
| 申请号 |
CA20112804889 |
申请日期 |
2011.07.15 |
| 申请人 |
ONYX PHARMACEUTICALS, INC. |
发明人 |
KERSCHEN, JAMES ALAN;BRIDGES, ALEXANDER JAMES;DALZIEL, SEAN MARK;DAPREMONT, OLIVIER;KIM, HYUNJUNG;THOMPSON, ANDREW S.;ZELLER, JAMES ROBERT |
| 分类号 |
C07D239/90;C07C235/04;C07C255/60 |
主分类号 |
C07D239/90 |
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