| 摘要 |
The present invention relates to novel antiviral active components of general formula 1, a pharmaceutical composition, an antiviral drug and a method for preventing and treating viral diseases, in particular diseases caused by the hepatitis C virus (HCV). In general formula 1, R1 is a hydrogen atom, optionally substituted C1C4 alkyl, C6 cycloalkyl, aryl, ethoxycarbonyl, a nitro group; R2 is a hydrogen atom; R3 is N-monosubstituted or NN-disubstituted 1-methylene-piperidine-3-carboxamide of general formula 1a or N-monosubstituted or NN-disubstituted 1-methylene-piperidine-4-carboxamide of general formula 1b; R4 is a hydrogen atom, optionally substituted C1-C3 alkyl; or R2 and R3 together with the carbon atoms to which they are bonded form substituted 2,3,4,9-tetrahydro-1H-carbazole of general formula 1.1, or R2, R3 and R4 together with the atoms to which they are bonded form a substituted nitrogen heterocycle of general formula 1.2; R5 and R6 are optionally identical and are a hydrogen atom, optionally substituted C1-C3 alkyl or C3-C6 cycloalkyl, or R5 and R6 together with the nitrogen atom to which they are bonded form an optionally substituted 5 or 6-membered nitrogen heterocycle which contains one or two nitrogen atoms and may be condensed with a benzene ring; R7 and R8 are hydrogen atoms, or R7 and R8 together with the carbon atom to which they are bonded form a C=O group; R9 is a nitrogen heterocycle containing at least one nitrogen atom, unsubstituted formamide, or phenyl, a substituted ethoxycarbonyl or nitro group; R10 is a hydrogen atom, optionally substituted C1-C3 alkyl, substituted acetyl; n = 1 or 2; and a broken line with an accompanying continuous line (---) represents a single or double bond.
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