发明名称 |
Crystal structure of human alpha-N-acetylglucosaminidase |
摘要 |
The present invention provides the three-dimensional structure of human α-N-acetylglucosaminidase (NAGLU) protein. This crystallographic information is useful in the identification and development of novel binding compounds of NAGLU, NAGLU mutants, for example, those associated with Sanfilippo syndrome type B (mucopolysaccharidosis III B (MPS III-B)), and other NAGLU family members (family 89 α-N-acetylglucosaminidase) which may modulate the activity and/or stability of mutated NAGLU. Such compounds may be useful for the treatment of Sanfilippo syndrome type B (mucopolysaccharidosis III B (MPS III-B)). |
申请公布号 |
US2012021436(A1) |
申请公布日期 |
2012.01.26 |
申请号 |
US201113136092 |
申请日期 |
2011.07.22 |
申请人 |
MEIYAPPAN MUTHURAMAN;CONCINO MICHAEL F.;NORTON ANGELA W.;SHIRE HUMAN GENETIC THERAPIES, INC. |
发明人 |
MEIYAPPAN MUTHURAMAN;CONCINO MICHAEL F.;NORTON ANGELA W. |
分类号 |
G01N33/566;G01N21/64;G06G7/58 |
主分类号 |
G01N33/566 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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