发明名称 |
METHOD OF CONTROLLING INITIAL DRUG RELEASE OF siRNA FROM SUSTAINED-RELEASE IMPLANTS |
摘要 |
<p>The present invention provides an intraocular implant comprising siRNA combined with a excipient effective to retard the initial release of the siRNA from an implant, wherein said siRNA and excipient is associated with a biocompatible polymer (e.g., a polymeric matrix), configured to release said siRNA into the eye of a patient at therapeutic levels for a time sufficient to treat an ocular condition or disease.</p> |
申请公布号 |
WO2012012546(A2) |
申请公布日期 |
2012.01.26 |
申请号 |
WO2011US44701 |
申请日期 |
2011.07.20 |
申请人 |
ALLERGAN, INC.;RIVERS, HONGWEN M.;SPADA, LON T.;LUU, MICHELLE |
发明人 |
RIVERS, HONGWEN M.;SPADA, LON T.;LUU, MICHELLE |
分类号 |
A61K9/00;A61K47/10;A61K47/26;A61K47/32;A61K47/36;A61K47/38;A61K47/40;A61K48/00 |
主分类号 |
A61K9/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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