发明名称 |
EFFICIENT INDUCTION OF PLURIPOTENT STEM CELLS USING SMALL MOLECULE COMPOUNDS |
摘要 |
The disclosure features a method of producing a reprogrammed cell (e.g. an induced pluripotent stem cell or an undifferentiated cell) from a differentiated (e.g. somatic) cell. In some embodiments, the methods includes contacting a differentiated (e.g. somatic cell) with a TGFBR1 inhibitor or anti-TGF-&bgr;-antibody to produce a reprogrammed cell (e.g. pluripotent stem cell or undifferentiated cell). Embodiments of the present invention relate to a reprogrammed cell and methods and compositions for producing a chemically produced reprogrammed cell or populations thereof.
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申请公布号 |
US2012021519(A1) |
申请公布日期 |
2012.01.26 |
申请号 |
US200913119848 |
申请日期 |
2009.09.21 |
申请人 |
ICHIDA JUSTIN;BLANCHARD JOEL;RUBIN LEE;EGGAN KEVIN;LAM KELVIN;PRESIDENTS AND FELLOWS OF HARVARD COLLEGE |
发明人 |
ICHIDA JUSTIN;BLANCHARD JOEL;RUBIN LEE;EGGAN KEVIN;LAM KELVIN |
分类号 |
C12N5/071 |
主分类号 |
C12N5/071 |
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