发明名称 RNA Interference Mediated Inhibition of the Thymic Stromal Lymphopoietin (TSLP) Gene Expression Using Short Interfering Nucliec Acid (siNA)
摘要 The present invention relates to compounds, compositions, and methods for the study, diagnosis, and treatment of traits, diseases and conditions that respond to the modulation of TSLP gene expression and/or activity, and/or modulate a TSLP gene expression pathway. Specifically, the invention relates to double-stranded nucleic acid molecules including small nucleic acid molecules, such as short interfering nucleic acid (siNA), short interfering RNA (siRNA), double-stranded RNA (dsRNA), micro-RNA (miRNA), and short hairpin RNA (shRNA) molecules that are capable of mediating or that mediate RNA interference (RNAi) against TSLP gene expression.
申请公布号 US2012022143(A1) 申请公布日期 2012.01.26
申请号 US201013256155 申请日期 2010.03.25
申请人 JADHAV VASANT;PICKERING VICTORIA;STRAPPS WALTER;MERCK SHARP & DOHME CORP 发明人 JADHAV VASANT;PICKERING VICTORIA;STRAPPS WALTER
分类号 A61K31/713;A61P11/00;A61P11/02;A61P11/06;A61P11/14;A61P29/00;C07H21/02 主分类号 A61K31/713
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