<p>A process for reducing dimethylamine content in metformin hydrochloride is disclosed. The process comprises: (a) providing metformin hydrochloride having dimethylamine content more than 15 ppm; (b) pulverizing the metformin hydrochloride; (c) slurrying the metformin hydrochloride in one or more Cj-C4 alcohol solvents; and (d) isolating the metformin hydrochloride.</p>
申请公布号
WO2010146604(A8)
申请公布日期
2012.01.26
申请号
WO2010IN00417
申请日期
2010.06.17
申请人
PATEL, PRANAV DUSHYANT AND PATEL, SHIVANI PRANAV TRADING AS EXEMED PHARMACEUTICALS, A PARTNERSHIP FIRM;PATEL, PRANAV, DUSHYANT;PATEL, DINESH, RAMANLAL