发明名称 INHIBITOR OF ANGIOPOIETIN-LIKE 4 PROTEIN, COMBINATION, AND THEIR USE
摘要 <P>PROBLEM TO BE SOLVED: To provide modulators of angiopoietin-like 4 protein, along with methods for their use in the treatment of diseases and pathological conditions. <P>SOLUTION: Combinations of ANGPTL4 antagonists and other therapeutics, e.g., anti-cancer agents, and methods of their use in the treatment of mammals susceptible to or diagnosed with cancer, or with relapse tumor growth or relapse cancer cell growth are provided. Also, combinations of inhibitors of ANGPTL4 and inhibitors of angiogenesis and methods of using such combinations to inhibit cancer growth and/or disorders involving angiogenesis are provided. <P>COPYRIGHT: (C)2012,JPO&INPIT
申请公布号 JP2012017331(A) 申请公布日期 2012.01.26
申请号 JP20110175420 申请日期 2011.08.10
申请人 GENENTECH INC 发明人 FERRARA NAPOLEONE;GERBER HANS-PETER;LIANG XIAO HUAN
分类号 A61K45/06;A61K31/7105;A61K39/395;A61K48/00;A61P35/00;A61P35/02;A61P43/00;C07K16/18;C12N15/09 主分类号 A61K45/06
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