发明名称 |
USE OF IL-12 AND IL-12 ANTAGONISTS IN THE TREATMENT OF AUTOIMMUNE DISEASES |
摘要 |
Method of treating autoimmune conditions are disclosed comprising administering to a mammalian subject IL-12 or an IL-12 antagonist. In certain preferred embodiments the autoimmune condition is one which is promoted by an increase in levels of IFN-γor TNF-α. Suitable conditions for treatment include multiple sclerosis, systemic lupus erythematosus, rheumatoid arthritis, autoimmune pulmonary inflammation, Guillain-Barre syndrome, autoimmune thyroiditis, insulin dependent diabetes melitis and autoimmune inflammatory eye disease.
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申请公布号 |
US2012020916(A1) |
申请公布日期 |
2012.01.26 |
申请号 |
US201113192920 |
申请日期 |
2011.07.28 |
申请人 |
LEONARD JOHN;GOLDMAN SAMUEL;O'HARA, JR. RICHARD;GENETICS INSTITUTE, L.L.C. |
发明人 |
LEONARD JOHN;GOLDMAN SAMUEL;O'HARA, JR. RICHARD |
分类号 |
A61K38/20;A61K38/00;A61K39/395;A61P3/10;A61P25/00;A61P27/02;A61P29/00;A61P37/06;C07K16/24;C12P21/08 |
主分类号 |
A61K38/20 |
代理机构 |
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