发明名称 |
Azabicyclo[3.1.0] hexane derivatives useful as modulators of dopamine D3 receptors |
摘要 |
<p>The present invention relates to novel compounds of formula (I) or a pharmaceutically acceptable salt thereof: wherein €¢ G is phenyl and (R 1 ) p is 4-trifluoromethyl; €¢ R 2 is hydrogen; €¢ R 3 is methyl; €¢ R 4 is 4-pyridazinyl; processes for their preparation, intermediates used in these processes, pharmaceutical compositions containing them and their use in therapy, as modulators of dopamine D 3 receptors, e.g. to treat drug dependency or as antipsychotic agents.</p> |
申请公布号 |
EP2060570(B1) |
申请公布日期 |
2012.01.25 |
申请号 |
EP20080169935 |
申请日期 |
2005.02.21 |
申请人 |
GLAXO GROUP LIMITED |
发明人 |
ARISTA, LUCA;BONANOMI, GIORGIO;CAPELLI, ANNA MARIA;DAMIANI, FEDERICA;DI FABIO, ROMANO;GENTILE, GABRIELLA;HAMPRECHT, DIETER;MICHELI, FABRIZIO;TARSI, LUCA;TEDESCO, GIOVANNA;TERRENI, SILVIA |
分类号 |
C07D403/14;A61K31/403;A61K31/501;A61P25/00;C07D401/14;C07D403/04;C07D403/12;C07D405/14;C07D413/14;C07D417/14;C07D471/08;C07D495/04 |
主分类号 |
C07D403/14 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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