发明名称 |
OB-fold used as scaffold for engineering new specific binders |
摘要 |
The present invention pertains to the field of protein engineering, and provides means for obtaining stable molecules that specifically bind to a target selected amongst a large variety of ligands families. In particular, the present invention provides methods for obtaining a molecule specifically binding to a target of interest, through a combinatorial mutation/selection approach with an OB-fold protein as a starting molecule. In particular, the target of interest can be of a different chemical nature form that of the native target of the OB-fold protein used as the starting molecule. |
申请公布号 |
EP1930342(B1) |
申请公布日期 |
2012.01.25 |
申请号 |
EP20060291869 |
申请日期 |
2006.12.04 |
申请人 |
INSTITUT PASTEUR;CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE |
发明人 |
PECORARI, FREDERIC;ALZARI, PEDRO |
分类号 |
C07K14/195;C12N15/10 |
主分类号 |
C07K14/195 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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