发明名称 |
FERTILITY TEST METHOD, POLYNUCLEOTIDE, POLYPEPTIDE AND ANTIBODY |
摘要 |
An object of the present invention is to provide a test/diagnosis method for fertility which allows the estimation of the possibility of leading to pregnancy based on the ability of sperm to fuse with an egg and the identification of a cause of infertility; and a polynucleotide and a fertility testing kit which are used in the method. The present invention provides a test/diagnosis method for fertility, including a detection step of detecting on a biological sample taken from a human body, the presence or absence of a deletion or mutation in the human PGAM4 gene; a polynucleotide consisting of the base sequence of the human wild-type PGAM4 gene or the base sequence of the translation region of the gene, wherein the polynucleotide consists of a base sequence of 10-100 consecutive bases containing a mutated site of a single base substitution mutation having a high correlation with fertility; and a test kit for fertility comprising a reagent for detecting the presence or absence of a deletion or mutation in the human PGAM4 gene. |
申请公布号 |
EP2410050(A1) |
申请公布日期 |
2012.01.25 |
申请号 |
EP20100753285 |
申请日期 |
2010.03.15 |
申请人 |
TOPPAN PRINTING CO., LTD.;OSAKA UNIVERSITY;KYUSHU BUNKA GAKUEN SCHOOL FOUNDATION |
发明人 |
IRIE, Shinji;TSUJIMURA, Akira;MIYAGAWA, Yasushi;TANAKA, Hiromitsu |
分类号 |
C12N15/09;C07K16/40;C12N9/90;C12Q1/533;C12Q1/68;G01N33/53 |
主分类号 |
C12N15/09 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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