发明名称 |
HIGH AFFINITY HUMAN ANTIBODIES TO PCSK9 |
摘要 |
An human antibody or antigen-binding fragment of a human antibody that specifically binds and inhibits human proprotein convertase subtilisin/kexin type 9 (hPCSK9) characterized by the ability to reduce serum LDL cholesterol by 40-80% over a 24, 60 or 90 day period relative to predose levels, with little or no reduction in serum HDL cholesterol and/or with little or no measurable effect on liver function, as determined by ALT and AST measurements. |
申请公布号 |
ZA201103762(B) |
申请公布日期 |
2012.01.25 |
申请号 |
ZA20110003762 |
申请日期 |
2011.05.23 |
申请人 |
REGENERON PHARMACEUTICALS, INC |
发明人 |
SLEEMAN MARK W;MARTIN JOEL H;HUANG TAMMY T;MACDONALD DOUGLAS;YANCOPOULOS ,GEORGE,D |
分类号 |
A61K;A61P;C07K;C12N |
主分类号 |
A61K |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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