发明名称 |
COMPOSITIONS AND METHODS FOR BLOOD-BRAIN BARRIER DELIVERY OF IGG-DECOY RECEPTOR FUSION PROTEINS |
摘要 |
Provided herein are compositions and related methods for delivering an IgG-decoy receptor to the CNS. The methods include systemic administration of a bifunctional decoy receptor-BBB receptor antibody fusion antibody comprising a receptor extracellular domain (ECD) covalently linked to an antibody to a receptor expressed on the surface of the blood-brain barrier (BBB receptor). In some embodiments, the compositions described herein are administered to treat a subject suffering from a CNS condition. |
申请公布号 |
EP2408474(A2) |
申请公布日期 |
2012.01.25 |
申请号 |
EP20100754139 |
申请日期 |
2010.03.18 |
申请人 |
ARMAGEN TECHNOLOGIES, INC. |
发明人 |
PARDRIDGE, WILLIAM, M.;BOADO, RUBEN, J. |
分类号 |
C07K19/00;A61K39/00;A61K47/48;C07H21/04;C07K14/715;C07K16/28;C12N15/00 |
主分类号 |
C07K19/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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