发明名称 |
Methods of treating OX40 mediated recall immune responses using OX40L antibodies and agents useful for identifying same |
摘要 |
T cell memory can persist in the absence of antigen. However, some memory cells by default are subject to signals accompanying periodic antigen exposure. OX40 is essential to the extent and persistence of Th2 memory when antigen is re-encountered. In an animal model of allergic asthma, inhibiting OX40/OX40L signaling during the secondary response to inhaled antigen suppressed lung inflammation. Inhibiting OX40 at the time of memory cell reactivation reduced the longevity of memory with further inflammation prevented upon tertiary encounter with antigen. |
申请公布号 |
US8101175(B1) |
申请公布日期 |
2012.01.24 |
申请号 |
US20080143077 |
申请日期 |
2008.06.20 |
申请人 |
CROFT MICHAEL;SALEK-ARDAKANI SHAHRAM;LA JOLLA INSTITUTE FOR ALLERGY AND IMMUNOLOGY |
发明人 |
CROFT MICHAEL;SALEK-ARDAKANI SHAHRAM |
分类号 |
A61K39/395 |
主分类号 |
A61K39/395 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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