发明名称 Substituted pyrrolo[2,3-d]pyrimidine as a protein kinase B inhibitor
摘要 The invention relates to a novel group of compounds of Formula (I) or salts thereof: wherein Y, Z1, Z2, R1, R4, R5 and n are as described in the specification, which may be useful in the treatment or prevention of a disease or medical condition mediated through protein kinase B (PKB) such as cancer. The invention also relates to pharmaceutical compositions comprising compounds of Formula (I), methods of treatment of diseases mediated by PKB using said compounds and methods for preparing compounds of Formula (I).
申请公布号 US8101623(B2) 申请公布日期 2012.01.24
申请号 US20080249477 申请日期 2008.10.10
申请人 LUKE RICHARD WILLIAM ARTHUR;MATUSIAK ZBIGNIEW STANLEY;ASTRAZENECA AB 发明人 LUKE RICHARD WILLIAM ARTHUR;MATUSIAK ZBIGNIEW STANLEY
分类号 C07D487/04;A61K31/519;A61P35/04 主分类号 C07D487/04
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