发明名称 |
Composition containing medicine extremely slightly soluble in water and method for preparation thereof |
摘要 |
A composition containing a very low water-soluble drug, which composition is produced by treating, with a supercritical or subcritical carbon dioxide fluid, a mixture containing a very low water-soluble drug and a porous material (exclusive of a porous silica material characterized in that the material has an average pore diameter of 1 to 20 nm, the total pore volume of the material that have a diameter falling within a range of ±40% of the average pore diameter account for 60% or more the volume of all the pores of the material, and, when subjected to X-ray diffractometry, the material exhibits one or more peaks at a diffraction angle (2&thetas;) corresponding to d of 1 nm or more); and a method for producing the composition. The very-low-water-soluble-drug-containing composition of the present invention ensures improved dissolution of the very low water-soluble drug. |
申请公布号 |
US8101207(B2) |
申请公布日期 |
2012.01.24 |
申请号 |
US20040551901 |
申请日期 |
2004.04.28 |
申请人 |
MIURA HIROSHI;KANEBAKO MAKOTO;KANISHI MASAYUKI;SHINODA YASUO;INAGI TOSHIO;TAKEUCHI HIROFUMI;KOWA CO., LTD. |
发明人 |
MIURA HIROSHI;KANEBAKO MAKOTO;KANISHI MASAYUKI;SHINODA YASUO;INAGI TOSHIO;TAKEUCHI HIROFUMI |
分类号 |
A61K9/20;A61K9/16;A61K31/50;A61K47/02;A61K47/04 |
主分类号 |
A61K9/20 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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