| 摘要 |
The present invention provides a peptide which functions as a mimic peptide of an amyloid &bgr; peptide and is capable of inhibiting the fibrillogenesis of an amyloid &bgr; peptide. The present invention relates to: an 8- to 30-amino acid residue peptide comprising an amino acid sequence represented by the following formula (I): X1-Asp-X2-X3-X4-Pro-X5-X6 (SEQ ID NO: 28)  (I) wherein X1 represents a branched chain amino acid, and X2, X3, X4, X5, and X6 are the same or different and each represents an α-amino acid; a 9- to 30-amino acid residue peptide comprising an amino acid sequence represented by the following formula (III): Z1-X13-Gly-X14-X15-Pro-Trp-Met-Z2 (SEQ ID NO: 31)  (III) wherein X13, X14, and X15 are the same or different and each represents an α-amino acid, Z1 and Z2 are the same or different and each represents cysteine or serine, and when Z1 and Z2 represent cysteine, they may be crosslinked; and a pharmaceutical composition and an amyloid &bgr; fibrillogenesis inhibitor comprising the peptide. |
