发明名称 |
Mycobacterial SecA2 mutants |
摘要 |
Provided are mycobacteria comprising (a) a mutation that is not in a SecA2 gene that attenuates the virulence of the mycobacteria in a mammalian host, and (b) a mutation in a SecA2 gene that eliminates SecA2 activity. Also provided are mycobacteria that comprise a mutation in a SecA2 gene that eliminates SecA2 activity, where the mycobacteria are not Mycobacterium tuberculosis or Mycobacterium smegmatis. Additionally provided are methods of inducing an immune response in a mammal and methods of inducing an immune response to a pathogenic mycobacterium in a human using the above mycobacterial mutants. |
申请公布号 |
US8101191(B2) |
申请公布日期 |
2012.01.24 |
申请号 |
US20070087628 |
申请日期 |
2007.01.11 |
申请人 |
JACOBS, JR. WILLIAM R.;PORCELLI STEVEN A.;BRAUNSTEIN MIRIAM;ALBERT EINSTEIN COLLEGE OF MEDICINE OF YESHIVA UNIVERSITY;THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL |
发明人 |
JACOBS, JR. WILLIAM R.;PORCELLI STEVEN A.;BRAUNSTEIN MIRIAM |
分类号 |
A61K39/04 |
主分类号 |
A61K39/04 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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