PHARMACEUTICAL COMPOSITION POSSESSING ANTIPSYCHOTIC, ANTIDEPRESSANT AND ANTIEPILEPTIC ACTIVITY WITH REDUCED SIDE EFFECT

摘要

FIELD: medicine, pharmaceutics. ^ SUBSTANCE: what is offered is application of O-(3-piperidino-2-hydroxy-1-propyl)-nicotinamidoxime or its pharmaceutically acceptable salt for preparing a pharmaceutical composition applicable for preventing or reducing a side effect represented by overweight or obesity in treating by an antipsychotic drug, and the pharmaceutical composition possess said action and contains the antipsychotic agent which when taken causes overweight or obesity, and O-(3-piperidino-2-hydroxy-1-propyl)-nicotinamidoxime or its pharmaceutically acceptable salt mixed with more than one common carrier. ^ EFFECT: reducing the declared side effect ensured by olanzapine, clozapine and risperidon is shown with metformin and rosiglitazone failed to prevent olanzapine-induced weight gain. ^ 8 cl, 3 tbl, 3 ex