| 摘要 |
FIELD: chemistry. ^ SUBSTANCE: invention relates to a cationic lypo-polymer, containing a polyethylene imine biodegradable group and a relative hydrophobic "lypo" group, or complex thereof with a biomolecule and consisting of recurring units selected from a group of formula and formula , where PEI denotes a polyethylene recurring unit; R is an electron pair; L is selected from a group consisting of C12-C18 fatty acids, cholesterol and derivatives thereof, C2-C50 alkyl, C2-C50 carboxyalkenyl, C2-C50 carboxyheteroalkenyl; W is a cationic part containing 2-50 carbon atoms; and m is a whole number from 1 to 30. The invention also describes methods of delivering a biomolecule to an eukaryotic cell, involving contact between the cell with said polymer. ^ EFFECT: obtaining polymers which can safely and effectively simplify delivery of biologically active agents to cells. ^ 20 cl, 19 ex, 15 dwg |
