Polymer coatings containing drug powder of controlled morphology

摘要

C:/Documnsand Scuin/pSXD/LalSettins/Tcmp/DcsCorp/OCR/3AGEo IOCRdo-L2/620II A method for depositing a coating comprising a polymer and pharmaceutical agent on a substrate, comprising the following steps: discharging at least one pharmaceutical agent in a therapeutically desirable morphology in dry powder form through a first orifice; discharging at least one polymer in dry powder form through a second orifice; depositing the polymer and/or pharmaceutical particles onto said substrate; wherein an electrical potential is maintained between the substrate and the pharmaceutical and/or polymer particles, thereby forming said coating; and sintering said coating under conditions that do not substantially modify the morphology of said pharmaceutical agent. 4-j 4-04 = ) I -j co0 xo: uit a, 6s....MAas S u H r -