| 发明名称 |
NOVEL P53-MDM2/P53-MDM4 ANTAGONISTS TO TREAT PROLIFERATIVE DISEASE |
| 摘要 |
High-resolution structural information delineates key interactions between MDM2 or MDM4 and heterocyclic compounds that bind to these proteins. These compounds are potent agonists of the p53-MDM2/p53-MDM4 complex. |
| 申请公布号 |
WO2011106650(A3) |
申请公布日期 |
2012.01.19 |
| 申请号 |
WO2011US26251 |
申请日期 |
2011.02.25 |
| 申请人 |
UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION;DOEMLING, ALEXANDER;HOLAK, TAD |
发明人 |
DOEMLING, ALEXANDER;HOLAK, TAD |
| 分类号 |
C07D403/04;A61K31/4155;A61K31/4178;A61P35/00;C07D403/14 |
主分类号 |
C07D403/04 |
| 代理机构 |
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