| 摘要 |
The invention relates to iRNA agents, which preferably include a monomer in which the ribose moiety has been 5 replaced by a moiety other than ribose. The inclusion of such a monomer can allow for modulation of a property of the iRNA agent into which it is incorporated, e.g., by using the non-ribose moiety as a point to which a ligand or other entity, e.g., a lipophilic moiety, e.g., 10 cholesterol, is directly, or indirectly, tethered. The invention also relates to methods of making and using such modified iRNA agents. 1509621_1 (GHMatters) 4/08/09 w 0==P-o.-0 0 tethering Ettachment point (R-2) backbone attachmnent points Carrier LIGAND RRMS 0 tethe w FG' 0 RH; A: crir R R R.= (- --- )+ (LIGAND) Fe2 |
