Administration of agents for the treatment of inflammation

摘要

A method of chronically reducing a patient's pathological inflammation via the administration of an agent that specifically binds to an alpha-4 integrin or a dimer comprising an alpha-4 integrin is disclosed. The agent provided must have a binding affinity such that administration is sufficient to suppress pathological inflammation, and the agent is administered chronically to provide long-term suppression of pathological inflammation. Clinical Response in the CD Study Cl' 50 30 - -0-- Placebo 20- ' - w- 3+0 S3+3 10- 6+6 0 2 4 6 8 10 12 Week Remission in the CD Study 40- c 300 E20 -0- Placebo -0E- 3+0 10 - 3+3 -+ -6+6 0 2 4 6 8 10 12 Week