发明名称 |
PURINE COMPOUNDS SELECTIVE FOR ?I3? P110 DELTA, AND METHODS OF USE |
摘要 |
The invention provides compounds having the general formula (I): and stereoisomers, tautomers, or pharmaceutically acceptable salts thereof, wherein R1, R2, R3, R4 and n are defined herein, compositions including the compounds and method of using the compounds to treat a disease or disorder mediated by the p110 delta isoform of ?I3 kinase selected from immune disorders, cancer, cardiovascular disease, viral infection, inflammation, metabolism/endocrine function disorders and neurological disorders. |
申请公布号 |
WO2012007493(A1) |
申请公布日期 |
2012.01.19 |
申请号 |
WO2011EP61930 |
申请日期 |
2011.07.13 |
申请人 |
F. HOFFMANN-LA ROCHE AG;LI, JUN;SAFINA, BRIAN;SUTHERLIN, DANIEL, P.;SWEENEY, ZACHARY |
发明人 |
LI, JUN;SAFINA, BRIAN;SUTHERLIN, DANIEL, P.;SWEENEY, ZACHARY |
分类号 |
C07D473/32;A61K31/52;A61P35/00 |
主分类号 |
C07D473/32 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|