发明名称 Crystallisation process for 1-(beta-D-glucopyranosyl)-4-methyl-3- [5-(4-fluorophenyl)-2-thienylmethyl] benzene
摘要 The present invention relates to a crystallisation procedure to obtain 1 -(β-D-glucopyranosyl)-4-methyl-3-[5-(4-fluorophenyl)-2-thienylmethyl] benzene hemihydrate crystals having a narrow particle size distribution and improved flowability, bulk and tap density properties.
申请公布号 AU2010270202(A1) 申请公布日期 2012.01.19
申请号 AU20100270202 申请日期 2010.07.08
申请人 JANSSEN PHARMACEUTICA NV 发明人 RAMMELOO, THOMAS JOACHIM LANDEWALD;DE KEYSER, RUBEN;SCHILDERMANS, GUSTAAF JOZEF PETRUS
分类号 C07D309/10 主分类号 C07D309/10
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