发明名称 |
ORTHOGONAL NUCLEIC ACID AFFINITY PAIRS |
摘要 |
The invention provides methods to identify pRNA- and pDNA oligomer affinity pairs. Affinity pairs comprised of nucleic acid oligomers which demonstrate no cross-reactivity (“orthogonal”) are designed using software and empirically verified by thermodynamic study and lateral flow testing. The design software uses a semi-random algorithm to build such sequences of nucleic acid oligomers based on user-input parameters for affinity strength and orthogonal stringency. These pairs can be applied for use in multi-analyte solid support and lateral flow diagnostic tests.
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申请公布号 |
US2012015358(A1) |
申请公布日期 |
2012.01.19 |
申请号 |
US201113185064 |
申请日期 |
2011.07.18 |
申请人 |
SCARR NOAH;LUKHTANOV EUGENY A.;ELITECH HOLDING B.V. |
发明人 |
SCARR NOAH;LUKHTANOV EUGENY A. |
分类号 |
C12Q1/68;C07H21/04;G01N33/53 |
主分类号 |
C12Q1/68 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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