发明名称 |
INHIBITORS OF SERINE PROTEASES, PARTICULARLY HCV NS3-NS4A PROTEASES |
摘要 |
The present invention relates to compounds of formula I: or a pharmaceutically acceptable salt, or mixtures thereof, that inhibit serine protease activity, particularly the activity of hepatitis C virus NS3-NS4A protease. As such, they act by interfering with the life cycle of the hepatitis C virus and are useful as antiviral agents. The invention further relates to pharmaceutically acceptable compositions comprising said compounds either for ex vivo use or for administration to a patient suffering from HCV infection and processes for preparing the compounds. The invention also relates to methods of treating an HCV infection in a patient by administering a pharmaceutical composition comprising a compound of this invention. |
申请公布号 |
US2012014914(A1) |
申请公布日期 |
2012.01.19 |
申请号 |
US201113238386 |
申请日期 |
2011.09.21 |
申请人 |
FARMER LUC J.;PERNI ROBERT B.;BHISETTI GOVINDA RAO;WILSON KEITH P.;VERTEX PHARMACEUTICALS INCORPORATED |
发明人 |
FARMER LUC J.;PERNI ROBERT B.;BHISETTI GOVINDA RAO;WILSON KEITH P. |
分类号 |
A61K38/21;A61K31/401;A61K31/407;A61K31/4155;A61K31/4178;A61K31/425;A61K31/427;A61K31/4745;A61K31/4965;A61K31/497;A61K31/5377;A61K31/7056;A61K38/04;A61K38/22;A61P31/14;C07D277/24;C07D401/12;C07D403/12;C07D413/14;C07D417/12;C07D471/02 |
主分类号 |
A61K38/21 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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