COMPOSITIONS AND METHODS FOR COMBINATIONS OF OLIGOAMINES WITH 2-DIFLUOROMETHYLORNITHINE (DFMO)
摘要
The present invention is based on the seminal discovery of a synergistic effect for combinations of oligoamines with 2-difluorornethylornithine (DFMO) for treatment of cancer. The invention provides combinations of at least one inhibitor of a histone demethylase enzyme and at least one inhibitor of ornithine decarboxylase (ODC). The invention also provides methods for treatment of cancer using such combinations and methods for altering methylation in a cell using such combinations. The invention provides that certain silenced genes can be re-expressed using combinations disclosed herein.
申请公布号
WO2011113005(A3)
申请公布日期
2012.01.19
申请号
WO2011US28206
申请日期
2011.03.11
申请人
THE JOHNS HOPKINS UNIVERSITY;PROGEN PHARMACEUTICALS;CASERO, ROBERT, A.;MARTON, LAURENCE, J.